Ontology highlight
ABSTRACT:
SUBMITTER: Obermayer J
PROVIDER: S-EPMC6173769 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Obermayer Joshua J Heistek Tim S TS Kerkhofs Amber A Goriounova Natalia A NA Kroon Tim T Baayen Johannes C JC Idema Sander S Testa-Silva Guilherme G Couey Jonathan J JJ Mansvelder Huibert D HD
Nature communications 20181005 1
A variety of inhibitory pathways encompassing different interneuron types shape activity of neocortical pyramidal neurons. While basket cells (BCs) mediate fast lateral inhibition between pyramidal neurons, Somatostatin-positive Martinotti cells (MCs) mediate a delayed form of lateral inhibition. Neocortical circuits are under control of acetylcholine, which is crucial for cortical function and cognition. Acetylcholine modulates MC firing, however, precisely how cholinergic inputs affect cortica ...[more]