Ontology highlight
ABSTRACT:
SUBMITTER: Lim SAO
PROVIDER: S-EPMC7854471 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Lim Sean Austin O SAO Surmeier D James DJ
Frontiers in systems neuroscience 20210120
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that initially manifests itself in the striatum. How intrastriatal circuitry is altered by the disease is poorly understood. To help fill this gap, the circuitry linking spiny projection neurons (SPNs) to cholinergic interneurons (ChIs) was examined using electrophysiological and optogenetic approaches in <i>ex vivo</i> brain slices from wildtype mice and zQ175<sup>+/-</sup> models of HD. These studies revealed a sever ...[more]