Ontology highlight
ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC6174029 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Chen S S Laverdiere I I Tourancheau A A Jonker D D Couture F F Cecchin E E Villeneuve L L Harvey M M Court M H MH Innocenti F F Toffoli G G Lévesque E E Guillemette C C
The pharmacogenomics journal 20150317 6
The risk of severe irinotecan-induced neutropenia has been shown to be related to the UGT1 variant UGT1A1*28, which increases exposure to the potent metabolite SN-38. Our goal was to identify a novel UGT1 marker(s) using 28 haplotype-tagged single nucleotide polymorphisms genotyped by mass spectrometry. By characterizing the UGT1 sequence from a cohort of 167 Canadian metastatic colorectal cancer (mCRC) patients and a validation cohort of 250 Italian mCRC patients, we found rs11563250G, located ...[more]