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Supramolecular Assemblies for Transporting Proteins Across an Immiscible Solvent Interface.

ABSTRACT: Polymeric supramolecular assemblies that can effectively transport proteins across an incompatible solvent interface are described. We show that electrostatics and ligand-protein interactions can be used to selectively transport proteins from an aqueous phase to organic phase. These transported proteins have been shown to maintain their tertiary structure and function. This approach opens up new possibilities for application of supramolecular assemblies in sensing, diagnostics and catalysis.

SUBMITTER: Gao J

PROVIDER: S-EPMC6174083 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Supramolecular Assemblies for Transporting Proteins Across an Immiscible Solvent Interface.

Gao Jingjing J Zhao Bo B Wang Meizhe M Serrano Mahalia A C MAC Zhuang Jiaming J Ray Moumita M Rotello Vincent M VM Vachet Richard W RW Thayumanavan S S

Journal of the American Chemical Society 20180212 7

Polymeric supramolecular assemblies that can effectively transport proteins across an incompatible solvent interface are described. We show that electrostatics and ligand-protein interactions can be used to selectively transport proteins from an aqueous phase to organic phase. These transported proteins have been shown to maintain their tertiary structure and function. This approach opens up new possibilities for application of supramolecular assemblies in sensing, diagnostics and catalysis. ...[more]

PMID: 29431433

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