Dataset Information

Optics-Free, Non-Contact Measurements of Fluids, Bubbles, and Particles in Microchannels Using Metallic Nano-Islands on Graphene.

ABSTRACT: Despite the apparent convenience of microfluidic technologies for applications in healthcare, such devices often rely on capital-intensive optics and other peripheral equipment that limit throughput. Here, we monitored the transit of fluids, gases, particles, and cells as they flowed through a microfluidic channel without the use of a camera or laser, i.e., "optics-free" microfluidics. We did this by monitoring the deformation of the side walls caused by the analyte passing through the channel. Critically, the analyte did not have to make contact with the channel walls to induce a deflection. This minute deformation was transduced into a change in electrical resistance using an ultrasensitive piezoresitive film composed of metallic nano-islands on graphene. We related changes in the resistance of the sensor to the theoretical deformation of the channel at varying flow rates. Then, we used air bubbles to induce a perturbation on the elastomeric channel walls and measured the viscoelastic relaxation of the walls of the channel. We obtained a viscoelastic time constant of 11.3 ± 3.5 s-1 for polydimethylsiloxane, which is consistent with values obtained using other techniques. Finally, we flowed silica particles and human mesenchymal stem cells and measured the deformation profiles of the channel. This technique yielded a convenient, continuous, and non-contact measurement of rigid and deformable particles without the use of a laser or camera.

SUBMITTER: Dhong C

PROVIDER: S-EPMC6174088 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Optics-Free, Non-Contact Measurements of Fluids, Bubbles, and Particles in Microchannels Using Metallic Nano-Islands on Graphene.

Dhong Charles C Edmunds Samuel J SJ Ramírez Julian J Kayser Laure V LV Chen Fang F Jokerst Jesse V JV Lipomi Darren J DJ

Nano letters 20180724 8

Despite the apparent convenience of microfluidic technologies for applications in healthcare, such devices often rely on capital-intensive optics and other peripheral equipment that limit throughput. Here, we monitored the transit of fluids, gases, particles, and cells as they flowed through a microfluidic channel without the use of a camera or laser, i.e., "optics-free" microfluidics. We did this by monitoring the deformation of the side walls caused by the analyte passing through the channel. ...[more]

PMID: 30024767

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Project description:Suspended particles flowing through complex porous spaces exhibit clogging mechanisms determined by factors including their size, deformability, and the geometry of the confinement. This study describes the clogging of rigid particles in a microfluidic device made up of parallel microchannels that taper from the inlet to the outlet, where the constriction width is approximately equal to the particle size. This converging geometry summarizes the dynamics of clogging in flow channels with constrictions that narrow over multiple length scales. Our novel approach allows the investigation of suspension flow dynamics in confined systems where clogs are formed both by sieving and bridging mechanisms simultaneously. Here, flow tests are conducted at constant driving pressures for different particle volume fractions, and a power-law decay which appears to be peculiar to the channels' tapered geometry is observed in all cases. Compared to non-tapered channels, the power-law behavior shows flowrate decay is significantly weaker in tapered channels. This weaker flowrate decay is explained by the formation of discontinuous clogs within each channel. Micrographs of the clogged channels reveal clogs do not grow continuously from their initial positions around the channels' outlet. Rather, new clogs spanning the width of the channel at their points of inception are successively formed as the cake grows toward the inlet area in each microchannel. The results show changes in particle volume fraction at constant driving pressure affect the clogging rate without impacting the underlying dynamics. Unexpectedly, analyses of the particles packing behavior in the microchannels, and post-clogging permeability of the microfluidic devices, reveal the presence of two distinct regimes of driving pressure, though only a small portion of the total device volume and channels surface area are occupied by clogs, regardless of the particle volume fraction. This novel investigation of discontinuous clogging over multiple particle diameters provides unique insights into additional mechanisms to control flow losses in filtration and other confined systems.

Dataset Information

Optics-Free, Non-Contact Measurements of Fluids, Bubbles, and Particles in Microchannels Using Metallic Nano-Islands on Graphene.

Publications

Optics-Free, Non-Contact Measurements of Fluids, Bubbles, and Particles in Microchannels Using Metallic Nano-Islands on Graphene.

Similar Datasets

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