Ontology highlight
ABSTRACT:
SUBMITTER: Arbour CA
PROVIDER: S-EPMC6175281 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Arbour Christine A CA Stamatin Ramona E RE Stockdill Jennifer L JL
The Journal of organic chemistry 20180125 4
Sequence diversification at the C terminus is traditionally limited by significant epimerization of the C-terminal residue during its activation toward nucleophilic attack, thus mandating repetition of the peptide synthesis for each targeted variation. Here, we accomplish divergent C-terminal elongation of a single peptide substrate with concomitant resin cleavage via displacement of an N-acyl urea moiety. Sterically hindered amino acids such as Ile and Pro are well-tolerated in this approach, w ...[more]