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A short-term in vivo model for Merkel Cell Carcinoma.

ABSTRACT: In vivo tumor models are essential for studying the biology of cancer, identifying tumor targets and evaluating antitumor drugs. Considering the request for the minimisation of animal experiments and following the "3R"-rule ("replacement," "refinement," "reduction"), it has become crucial to develop alternative experimental models in cancer biology. Several studies have already described the avian chorioallantoic membrane (CAM) model as an alternative to rodents, suitable to investigate growth, progression and metastasis of various types of cancer. In the present work, we grafted three Merkel cell carcinoma (MCC) cell lines onto the avian CAM and monitored tumor growth and development of solid tumor nodules. Morphology of xenograft was characterised histologically and immunohistochemically. Our results demonstrate CAM assay as a useful tool to study MCC pathophysiology.

SUBMITTER: Bhat VK

PROVIDER: S-EPMC6175323 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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A short-term in vivo model for Merkel Cell Carcinoma.

Bhat Vishwanath Kumble VK Krump Corinna C Bernhart Eva E Becker Jürgen C JC Sattler Wolfgang W Ghaffari-Tabrizi-Wizsy Nassim N

Experimental dermatology 20180326 6

In vivo tumor models are essential for studying the biology of cancer, identifying tumor targets and evaluating antitumor drugs. Considering the request for the minimisation of animal experiments and following the "3R"-rule ("replacement," "refinement," "reduction"), it has become crucial to develop alternative experimental models in cancer biology. Several studies have already described the avian chorioallantoic membrane (CAM) model as an alternative to rodents, suitable to investigate growth, ...[more]

PMID: 29509994

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Merkel Cell Polyomavirus and Merkel Cell Carcinoma.

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Merkel cell polyomavirus and Merkel cell carcinoma.

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Project description: Not available

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A short-term in vivo model for giant cell tumor of bone.

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Merkel Cell Carcinoma.

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Merkel cell carcinoma.

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Merkel cell polyomavirus in Merkel cell carcinoma of Italian patients.

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Merkel cell polyomavirus strains in patients with merkel cell carcinoma.

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Prokineticins and Merkel cell polyomavirus infection in Merkel cell carcinoma.

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| S-EPMC3960603 | biostudies-literature

Feline papillomavirus-associated Merkel cell carcinoma: a comparative review with human Merkel cell carcinoma.

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