In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy.
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ABSTRACT:
SUBMITTER: Jonas O
PROVIDER: S-EPMC6175619 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy.
Jonas Oliver O Kang Jeon Woong JW Singh Surya P SP Lammers Alex A Nguyen Freddy T FT Dasari Ramachandra R RR So Peter T C PTC Langer Robert R Cima Michael J MJ
The Analyst 20181001 20
We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes. ...[more]
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