Ontology highlight
ABSTRACT:
SUBMITTER: Peek J
PROVIDER: S-EPMC6175910 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Peek James J Lilic Mirjana M Montiel Daniel D Milshteyn Aleksandr A Woodworth Ian I Biggins John B JB Ternei Melinda A MA Calle Paula Y PY Danziger Michael M Warrier Thulasi T Saito Kohta K Braffman Nathaniel N Fay Allison A Glickman Michael S MS Darst Seth A SA Campbell Elizabeth A EA Brady Sean F SF
Nature communications 20181008 1
Rifamycin antibiotics (Rifs) target bacterial RNA polymerases (RNAPs) and are widely used to treat infections including tuberculosis. The utility of these compounds is threatened by the increasing incidence of resistance (Rif<sup>R</sup>). As resistance mechanisms found in clinical settings may also occur in natural environments, here we postulated that bacteria could have evolved to produce rifamycin congeners active against clinically relevant resistance phenotypes. We survey soil metagenomes ...[more]