Ontology highlight
ABSTRACT:
SUBMITTER: Guda MR
PROVIDER: S-EPMC6176187 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Guda Maheedhara R MR Asuthkar Swapna S Labak Collin M CM Tsung Andrew J AJ Alexandrov Ilya I Mackenzie Malcolm J MJ Prasad Durbaka Vr DV Velpula Kiran K KK
American journal of cancer research 20180901 9
Dysregulated metabolism in the form of aerobic glycolysis occurs in many cancers including breast carcinoma. Here, we report PDK4 (pyruvate dehydrogenase kinase 4) as key enzyme implicated in the control of glucose metabolism and mitochondrial respiration is relatively highly expressed in breast cancers, and its expression correlates with poor patient outcomes. Silencing of PDK4 and ectopic expression of miR-211 attenuates PDK4 expression in breast cancer cells. Interestingly, low miR-211 expres ...[more]