Ontology highlight
ABSTRACT:
SUBMITTER: Lin CC
PROVIDER: S-EPMC6945120 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Lin Chang-Ching CC Lo Miao-Chia MC Moody Rebecca R Jiang Hui H Harouaka Ramdane R Stevers Nicholas N Tinsley Samantha S Gasparyan Mari M Wicha Max M Sun Duxin D
Cancer letters 20180915
Triple-negative breast cancer (TNBC) is the most difficult subtype of breast cancer to treat due to a paucity of effective targeted therapies. Many studies have reported that breast cancer stem cells (BCSCs) are enriched in TNBC and are responsible for chemoresistance and metastasis. In this study, we identify LRP8 as a novel positive regulator of BCSCs in TNBC. LRP8 is highly expressed in TNBC compared to other breast cancer subtypes and its genomic locus is amplified in 24% of TNBC tumors. Kno ...[more]