Dataset Information

Treatment of hyperphosphatemia based on specific interactions between phosphorus and Zr(iv) active centers of nano-MOFs.

ABSTRACT: Hyperphosphatemia is closely associated with the occurrence of multiple organ dysfunctions in patients with end-stage renal disease (ESRD). The application of phosphorus binders as an effective clinical approach for such diseases still suffers from serious side effects. Therefore, development of new phosphorus binders for the treatment of hyperphosphatemia remains a great challenge. Herein, we describe a kind of zirconium (Zr(iv))-based nano-MOF that is well suited for specific adsorption and selective fluorescence sensing of phosphate, and is based on the particular interactions between Zr(iv) and phosphate. The reduced levels of phosphate were quantitatively monitored using the MOF-based fluorescence nanosensor. Notably, the MOFs exhibit a greater reduction in phosphorus levels than commercially available phosphorus binders, and comparable therapeutic effects in the treatment of hyperphosphatemia of a mice model. Hence, the MOF acts as a promising medication for hyperphosphatemia by directly adsorbing phosphorus in the blood, which offers new perspectives in future applications of MOFs.

SUBMITTER: Zhang W

PROVIDER: S-EPMC6176778 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Treatment of hyperphosphatemia based on specific interactions between phosphorus and Zr(iv) active centers of nano-MOFs.

Zhang Wei W Xu Jiheng J Li Ping P Gao Xiaonan X Zhang Wen W Wang Hui H Tang Bo B

Chemical science 20180723 38

Hyperphosphatemia is closely associated with the occurrence of multiple organ dysfunctions in patients with end-stage renal disease (ESRD). The application of phosphorus binders as an effective clinical approach for such diseases still suffers from serious side effects. Therefore, development of new phosphorus binders for the treatment of hyperphosphatemia remains a great challenge. Herein, we describe a kind of zirconium (Zr(iv))-based nano-MOF that is well suited for specific adsorption and se ...[more]

PMID: 30319748

Similar Datasets

Project description:As the world population continues to grow, there is also a rising concern regarding water pollution since this condition could negatively impact the supply of clean water. One of the most recent concerns is related to the pollution that comes from various pharmaceuticals, in particular non-steroidal anti-inflammatory drugs (NSAIDs) since they have been industrially produced at large scale and can be easily purchased as an over-the-counter medicine. Diclofenac is one of the most popular NSAIDs because of its high-effectiveness, which leads to its excessive consumption. Consequently, its presence in water bodies is also continuously increasing. An adsorption process could then be employed as a highly effective method to address this issue. In comparison to other conventional adsorbents such as activated carbon, the use of metal-organic frameworks (MOFs) as an alternative adsorbent is very attractive since it can offer various advantages such as tailorability and high adsorption capacity. In this study, the performance of three water-stable, free-base porphyrin MOFs assembled using zirconia-based nodes, namely MOF-525, MOF-545, and NU-902, for diclofenac adsorption was thoroughly investigated. Interestingly, although all three free-base porphyrin MOFs are assembled using the same building block and have a similar specific surface area (based on the experimental argon physisorption and calculation based on non-localized density functional theory), their diclofenac adsorption capacity is substantially different from one another. It is found that the highest diclofenac adsorption capacity is shown by MOF-525, which has maximum capacity around 792 mg g-1. This is then followed by MOF-545 and NU-902 that have adsorption capacities around 591 and 486 mg g-1, respectively. Some possible adsorption mechanisms are then thoroughly discussed that might contribute to this phenomenon. Lastly, their performance is also compared with other MOFs that are also studied for this purpose to show their performance superiority not only in terms of adsorption capacity but also their affinity towards the diclofenac molecule, which might be useful as an adsorption performance indicator in the real condition where the contaminant concentration is considerably low.

Dataset Information

Treatment of hyperphosphatemia based on specific interactions between phosphorus and Zr(iv) active centers of nano-MOFs.

Publications

Treatment of hyperphosphatemia based on specific interactions between phosphorus and Zr(iv) active centers of nano-MOFs.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets