Ontology highlight
ABSTRACT:
SUBMITTER: Pouyet F
PROVIDER: S-EPMC6177262 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Pouyet Fanny F Aeschbacher Simon S Thiéry Alexandre A Excoffier Laurent L
eLife 20180823
Disentangling the effect on genomic diversity of natural selection from that of demography is notoriously difficult, but necessary to properly reconstruct the history of species. Here, we use high-quality human genomic data to show that purifying selection at linked sites (i.e. background selection, BGS) and GC-biased gene conversion (gBGC) together affect as much as 95% of the variants of our genome. We find that the magnitude and relative importance of BGS and gBGC are largely determined by va ...[more]