Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC6177327 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Wang Chao C Zhu Wandi W Luo Yuan Y Wang Bao-Zhong BZ
Nanomedicine : nanotechnology, biology, and medicine 20180409 4
The immunogenicity of subunit vaccines can be augmented by formulating them into nanoparticles. We conjugated recombinant trimetric influenza A/Aichi/2/68(H3N2) hemagglutinin (HA) onto functionalized gold nanoparticle (AuNP) surfaces in a repetitive, oriented configuration. To further improve the immunogenicity, we generated Toll-like receptor 5 (TLR5) agonist flagellin (FliC)-coupled AuNPs as particulate adjuvants. Intranasal immunizations with an AuNP-HA and AuNP-FliC particle mixture elicited ...[more]