Ontology highlight
ABSTRACT:
SUBMITTER: Downes M
PROVIDER: S-EPMC6179153 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Molecular cell 20030401 4
The farnesoid X receptor (FXR) functions as a bile acid (BA) sensor coordinating cholesterol metabolism, lipid homeostasis, and absorption of dietary fats and vitamins. However, BAs are poor reagents for characterizing FXR functions due to multiple receptor independent properties. Accordingly, using combinatorial chemistry we evolved a small molecule agonist termed fexaramine with 100-fold increased affinity relative to natural compounds. Gene-profiling experiments conducted in hepatocytes with ...[more]