Ontology highlight
ABSTRACT:
SUBMITTER: Ibanez M
PROVIDER: S-EPMC6179200 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Ibáñez Mariam M Carbonell-Caballero José J Such Esperanza E García-Alonso Luz L Liquori Alessandro A López-Pavía María M Llop Marta M Alonso Carmen C Barragán Eva E Gómez-Seguí Inés I Neef Alexander A Hervás David D Montesinos Pau P Sanz Guillermo G Sanz Miguel Angel MA Dopazo Joaquín J Cervera José J
PloS one 20181010 10
Acute myeloid leukemia (AML) is associated with the sequential accumulation of acquired genetic alterations. Although at diagnosis cytogenetic alterations are frequent in AML, roughly 50% of patients present an apparently normal karyotype (NK), leading to a highly heterogeneous prognosis. Due to this significant heterogeneity, it has been suggested that different molecular mechanisms may trigger the disease with diverse prognostic implications. We performed whole-exome sequencing (WES) of tumor- ...[more]