Ontology highlight
ABSTRACT:
SUBMITTER: Fine M
PROVIDER: S-EPMC6180102 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nature communications 20181010 1
Transient receptor potential mucolipin 1 (TRPML1), a lysosomal channel, maintains the low pH and calcium levels for lysosomal function. Several small molecules modulate TRPML1 activity. ML-SA1, a synthetic agonist, binds to the pore region and phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P<sub>2</sub>), a natural lipid, stimulates channel activity to a lesser extent than ML-SA1; moreover, PtdIns(4,5)P<sub>2</sub>, another natural lipid, prevents TRPML1-mediated calcium release. Notably, Ptd ...[more]