Ontology highlight
ABSTRACT:
SUBMITTER: Zuo H
PROVIDER: S-EPMC6486783 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Zuo Hao H Glaaser Ian I Zhao Yulin Y Kurinov Igor I Mosyak Lidia L Wang Haonan H Liu Jonathan J Park Jinseo J Frangaj Aurel A Sturchler Emmanuel E Zhou Ming M McDonald Patricia P Geng Yong Y Slesinger Paul A PA Fan Qing R QR
Proceedings of the National Academy of Sciences of the United States of America 20190410 17
Metabotropic GABA<sub>B</sub> receptors mediate a significant fraction of inhibitory neurotransmission in the brain. Native GABA<sub>B</sub> receptor complexes contain the principal subunits GABA<sub>B1</sub> and GABA<sub>B2</sub>, which form an obligate heterodimer, and auxiliary subunits, known as potassium channel tetramerization domain-containing proteins (KCTDs). KCTDs interact with GABA<sub>B</sub> receptors and modify the kinetics of GABA<sub>B</sub> receptor signaling. Little is known ab ...[more]