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Expression of mitofusin 2 in human sperm and its relationship to sperm motility and cryoprotective potentials.

ABSTRACT: Mitofusin 2 is a kind of mitochondria membrane protein that has been implicated in maintenance of mitochondrial morphology and function. However, the expression and function of mitofusin 2 in human sperm are not well described at present. The aim of this study was to explore the location of mitofusin 2 in human sperm and to discover its relationship to human sperm functions like motility and cryoprotective potentials. Our result showed that mitofusin 2 is specifically localized in the 5-7 ?m midpiece between the neck and main part of human sperm tail. The expression level of mitofusin 2 in human sperm was significantly different between the normozoospermia and asthenozoospermia groups ( P?40%) was significantly higher than that of the freeze-intolerant group (cryo-survival rate ?40%) ( P?

SUBMITTER: Fang F

PROVIDER: S-EPMC6180404 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Expression of mitofusin 2 in human sperm and its relationship to sperm motility and cryoprotective potentials.

Fang Fang F Ni Ke K Shang Jin J Zhang Xiaoke X Xiong Chengliang C Meng Tianqing T

Experimental biology and medicine (Maywood, N.J.) 20180730 12

Mitofusin 2 is a kind of mitochondria membrane protein that has been implicated in maintenance of mitochondrial morphology and function. However, the expression and function of mitofusin 2 in human sperm are not well described at present. The aim of this study was to explore the location of mitofusin 2 in human sperm and to discover its relationship to human sperm functions like motility and cryoprotective potentials. Our result showed that mitofusin 2 is specifically localized in the 5-7 μm mid ...[more]

PMID: 30058380

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