Brain-derived neurotrophic factor, a new soluble biomarker for malignant pleural mesothelioma involved in angiogenesis.
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ABSTRACT:
SUBMITTER: Smeele P
PROVIDER: S-EPMC6180566 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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Brain-derived neurotrophic factor, a new soluble biomarker for malignant pleural mesothelioma involved in angiogenesis.
Smeele Patrick P d'Almeida Sènan Mickaël SM Meiller Clément C Chéné Anne-Laure AL Liddell Charly C Cellerin Laurent L Montagne François F Deshayes Sophie S Benziane Sarah S Copin Marie-Christine MC Hofman Paul P Le Pimpec-Barthes Françoise F Porte Henri H Scherpereel Arnaud A Grégoire Marc M Jean Didier D Blanquart Christophe C
Molecular cancer 20181011 1
Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer related to asbestos exposure. The discovery of soluble biomarkers with diagnostic/prognostic and/or therapeutic properties would improve therapeutic care of MPM patients. Currently, soluble biomarkers described present weaknesses preventing their use in clinic. This study aimed at evaluating brain-derived neurotrophic factor (BDNF), we previously identified using transcriptomic approach, in MPM. We observed that high BDNF expre ...[more]
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