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Effects of 4 weeks of ?-alanine supplementation on aerobic fitness in water polo players.

ABSTRACT: The purpose of the present study was to investigate the ergogenic effects of 4 weeks of ?-alanine supplementation on peak oxygen uptake ([Formula: see text]) and force associated with [Formula: see text] ([Formula: see text]) during a tethered swimming graded exercise test, and a three-minute all-out effort (3minALL-OUT) in water polo players. Twenty-two male national competitive level water polo players were randomly assigned to receive either 4 weeks of ?-alanine (n = 11) or a placebo (n = 11) (i.e., 4.8 g·day-1 for 10 days, then6.4 g·day-1 for 18 days, resulting in 163.2 g over 28 days). The participants performed the TSGET and 3minALL-OUT before and after the supplementation period. There were no significant interaction effects between-groups for any variable, however, the magnitude-based inferences analyses showed a possibly beneficial effect (74%) of ?-alanine supplementation on [Formula: see text] compared to placebo treatment (?% [post-pre] for Placebo group = -5.2%; ?% [post-pre] for ?-alanine group = +0.7%). Only the ?-alanine group presented a significant reduction in [Formula: see text] expressed in absolute values (PRE = 3.3±0.6L·min-1; POST = 3.0±0.4L·min-1; p = .021). Similarly, only the ?-alanine group presented a significant increase in critical force (PRE = 51.2±10.4N; POST = 56.5±13.1N; p = .044) and a reduction in the curvature constant parameter (W'; PRE = 2998.0±1103.7N·s; POST = 2224.6±1058.9N·s; p = .049). Thus, we can conclude that 4 weeks of ?-alanine supplementation presented mixed results in water polo players, indicating that this nutritional strategy may not be effective in improving parameters of the TSGET and 3minALL-OUT .

SUBMITTER: Brisola GMP

PROVIDER: S-EPMC6181339 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Effects of 4 weeks of β-alanine supplementation on aerobic fitness in water polo players.

Brisola Gabriel Motta Pinheiro GMP Redkva Paulo Eduardo PE Pessôa Filho Dalton Muller DM Papoti Marcelo M Zagatto Alessandro Moura AM

PloS one 20181011 10

The purpose of the present study was to investigate the ergogenic effects of 4 weeks of β-alanine supplementation on peak oxygen uptake ([Formula: see text]) and force associated with [Formula: see text] ([Formula: see text]) during a tethered swimming graded exercise test, and a three-minute all-out effort (3minALL-OUT) in water polo players. Twenty-two male national competitive level water polo players were randomly assigned to receive either 4 weeks of β-alanine (n = 11) or a placebo (n = 11) ...[more]

PMID: 30307991

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Project description:BackgroundShoulders of throwing and swimming athletes are highly stressed joints that often show structural abnormalities on magnetic resonance imaging (MRI). However, while water polo players exhibit a combination of throwing and swimming movements, a specific pattern of pathological findings has not been described.PurposeTo assess specific MRI abnormalities in shoulders of elite water polo players and to compare these findings with a healthy control group.Study designCross-sectional study; Level of evidence, 3.MethodsAfter performing a power analysis, volunteers were recruited for this study. Both shoulders of 28 semiprofessional water polo players and 15 healthy volunteers were assessed clinically (based on the Constant score) and had bilateral shoulder MRIs. The shoulders were clustered into 3 groups: 28 throwing and 28 nonthrowing shoulders of water polo athletes and 30 shoulders of healthy control subjects.ResultsTwenty-eight male water polo players with an average age of 24 years and 15 healthy subjects (30 shoulders) with an average age of 31 years were examined. Compared with controls, significantly more MRI abnormalities in the water polo players' throwing shoulders could be found in the subscapularis, infraspinatus, and posterior labrum (P = .001, P = .024, and P = .041, respectively). Other structures showed no statistical differences between the 3 groups, including the supraspinatus tendon, which had abnormalities in 36% of throwing versus 32% of nonthrowing shoulders and 33% of control shoulders. All throwing shoulders showed abnormal findings in the MRI, but only 8 (29%) were symptomatic.ConclusionThe shoulders of semiprofessional water polo players demonstrated abnormalities in subscapularis and infraspinatus tendons that were not typical abnormalities for swimmers or throwing athletes.Clinical relevanceThe throwing shoulders of water polo players have specific MRI changes. Clinical symptoms do not correlate with the MRI findings.

Project description:BackgroundBeta-alanine (BA) supplementation increases muscle carnosine, an abundant endogenous antioxidant and pH buffer in skeletal muscle. Carnosine loading promotes exercise capacity in healthy older adults. As patients with chronic obstructive pulmonary disease (COPD) suffer from elevated exercise-induced muscle oxidative/carbonyl stress and acidosis, and from reduced muscle carnosine stores, it was investigated whether BA supplementation augments muscle carnosine and induces beneficial changes in exercise capacity, quadriceps function, and muscle oxidative/carbonyl stress in patients with COPD.MethodsIn this double-blind, randomized, placebo (PL)-controlled trial (clinicaltrials.gov identifier: NCT02770417), 40 patients (75% male) with COPD (mean ± standard deviation: age 65 ± 6 years; FEV1 % predicted 55 ± 14%) were assigned to 12 weeks oral BA or PL supplementation (3.2 g/day). The primary outcome, i.e. muscle carnosine, was quantified from m. vastus lateralis biopsies obtained before and after intervention. Co-primary outcomes, i.e. incremental and constant work rate cycle capacity, were also assessed. Linear mixed model analyses were performed. Compliance with and side effects of supplement intake and secondary outcomes (quadriceps strength and endurance, and muscle oxidative/carbonyl stress) were also assessed.ResultsBeta-alanine supplementation increased muscle carnosine in comparison with PL in patients with COPD (mean difference [95% confidence interval]; +2.82 [1.49-4.14] mmol/kg wet weight; P < 0.001). Maximal incremental cycling capacity (VO2 peak: +0.5 [-0.7 to 1.7] mL/kg/min; P = 0.384, Wpeak: +5 [-1 to 11] W; P = 0.103) and time to exhaustion on the constant work rate cycle test (+28 [-179 to 236] s; P = 0.782) did not change significantly. Compliance with supplement intake was similar in BA (median (quartile 1-quartile 3); 100 (98-100)%) and PL (98 (96-100)%) (P = 0.294) groups, and patients did not report side effects possibly related to supplement intake. No change was observed in secondary outcomes.ConclusionsBeta-alanine supplementation is efficacious in augmenting muscle carnosine (+54% from mean baseline value) without side effects in patients with COPD in comparison with PL. However, accompanied beneficial changes in exercise capacity, quadriceps function, and muscle oxidative/carbonyl stress were not observed.

Project description:There is growing evidence that severe decline of skeletal muscle mass and function with age may be mitigated by exercise and dietary supplementation with protein and amino acid ingredient technologies. The purposes of this study were to examine the effects of the leucine catabolite, beta-hydroxy-beta-methylbutyrate (HMB), in C2C12 myoblasts and myotubes, and to investigate the effects of dietary supplementation with HMB, the amino acid β-alanine and the combination thereof, on muscle contractility in a preclinical model of pre-sarcopenia. In C2C12 myotubes, HMB enhanced sarcoplasmic reticulum (SR) calcium release beyond vehicle control in the presence of all SR agonists tested (KCl, P<0.01; caffeine, P = 0.03; ionomycin, P = 0.03). HMB also improved C2C12 myoblast viability (25 μM HMB, P = 0.03) and increased proliferation (25 μM HMB, P = 0.04; 125 μM HMB, P<0.01). Furthermore, an ex vivo muscle contractility study was performed on EDL and soleus muscle from 19 month old, male C57BL/6nTac mice. For 8 weeks, mice were fed control AIN-93M diet, diet with HMB, diet with β-alanine, or diet with HMB and β-alanine. In β-alanine fed mice, EDL muscle showed a 7% increase in maximum absolute force compared to the control diet (202 ± 3vs. 188± 5 mN, P = 0.02). At submaximal frequency of stimulation (20 Hz), EDL from mice fed HMB plus β-alanine showed an 11% increase in absolute force (88.6 ± 2.2 vs. 79.8 ± 2.4 mN, P = 0.025) and a 13% increase in specific force (12.2 ± 0.4 vs. 10.8 ± 0.4 N/cm2, P = 0.021). Also in EDL muscle, β-alanine increased the rate of force development at all frequencies tested (P<0.025), while HMB reduced the time to reach peak contractile force (TTP), with a significant effect at 80 Hz (P = 0.0156). In soleus muscle, all experimental diets were associated with a decrease in TTP, compared to control diet. Our findings highlight beneficial effects of HMB and β-alanine supplementation on skeletal muscle function in aging mice.

Dataset Information

Effects of 4 weeks of ?-alanine supplementation on aerobic fitness in water polo players.

Publications

Effects of 4 weeks of β-alanine supplementation on aerobic fitness in water polo players.

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