Ontology highlight
ABSTRACT:
SUBMITTER: Vervoort SJ
PROVIDER: S-EPMC6182182 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Vervoort Stephin J SJ Lourenço Ana Rita AR Tufegdzic Vidakovic Ana A Mocholi Enric E Sandoval José L JL Rueda Oscar M OM Frederiks Cynthia C Pals Cornelieke C Peeters Janneke G C JGC Caldas Carlos C Bruna Alejandra A Coffer Paul J PJ
Nucleic acids research 20181001 18
Expression of the transcription factor SOX4 is often elevated in human cancers, where it generally correlates with tumor-progression and poor-disease outcome. Reduction of SOX4 expression results in both diminished tumor-incidence and metastasis. In breast cancer, TGF-β-mediated induction of SOX4 has been shown to contribute to epithelial-to-mesenchymal transition (EMT), which controls pro-metastatic events. Here, we identify SMAD3 as a novel, functionally relevant SOX4 interaction partner. Geno ...[more]