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GENETICS : ASSOCIATION OF GENETIC VARIATION OF TOMM40 WITH COGNITIVE DECLINE IN OLDER ADULTS: THE SONIC STUDY

ABSTRACT: Abstract Background: It is reported that single nucleotide polymorphism (SNP) of the Translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene is significantly associated with late-onset Alzheimer’s disease and cognitive decline in various ethnic groups. The aim of this study is to clarify the association of rs2075650 in TOMM40 with cognitive function among 70- and 80-year-old Japanese general population. Methods: Participants in age 70?±?1 and 80?±?1 years (n=550, 517 respectively) were randomly recruited from general population participating in the study of Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) study, and part of them received follow-up investigation after 3 years. Written informed consent for genetic analysis was obtained from study participants. Rs2075650 in DNA extracted from blood samples was genotyped by TaqMan PCR method. Cognitive function was measured by the Montreal Cognitive Assessment (MoCA-J). Association of SNP with cognitive function is analyzed by the multiple regression models adjusting potential confounding factors. Results: There were no significant differences of MoCA-J total score at baseline among each allele in rs2075650 both in 70 and 80 years participants. However, in 80 years participants, there was significant differences in MoCA-J total score among alleles in rs2075650 (AA, GA, GG; 22.0, 21.2, 18.3, respectively; p=0.008) at follow-up examination. In addition, the TOMM40 (G allele) was significantly associated with a greater decline in MoCA-J total score at follow-up (?=-0.14; p=0.002), and the effect appeared to be greater in females (?=-0.21; p=0.001), but not in males and in 70 years participants. Conclusions:TOMM40 rs2075650 is an independent associated factor of cognitive function in Japanese females aged around 80.

SUBMITTER: Ryuno H

PROVIDER: S-EPMC6184415 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Project description:ImportanceAssociations between visual and global cognitive impairments have been previously documented, but there is limited research examining these associations between multiple measures of vision across cognitive domains.ObjectiveTo examine the association between vision and cognitive across multiple cognitive domains using multiple measures of vision.Design, setting, and participantsThis longitudinal cohort study used data from the Baltimore Longitudinal Study of Aging for 2003 to 2019. Participants in the current study were aged 60 to 94 years with vision and cognitive measures. Data analysis was performed from May 2020 to May 2021.Main outcomes and measuresCognitive function was measured across multiple domains, including language, memory, attention, executive function, and visuospatial ability. Cognitive domain scores were calculated as the mean of standardized cognitive test scores within each domain. Visual function was assessed using measures of visual acuity, contrast sensitivity, and stereo acuity at baseline.ResultsAnalyses included 1202 participants (610 women [50.8%]; 853 White participants [71.0%]) with a mean (SD) age of 71.1 (8.6) years who were followed up for a mean (SD) of 6.9 (4.7) years. Worse visual acuity (per 0.1 logarithm of the minimal angle of resolution) at baseline was associated with greater declines in language (β, -0.0035; 95% CI, -0.007 to -0.001) and memory (β, -0.0052; 95% CI, -0.010 to -0.001) domain scores. Worse contrast sensitivity (per 0.1 log units) at baseline was associated with greater declines in language (β, -0.010; 95% CI, -0.014 to -0.006), memory (β, -0.009; 95% CI, -0.015 to -0.003), attention (β, -0.010; 95% CI, -0.017 to -0.003), and visuospatial ability (β, -0.010; 95% CI, -0.017 to -0.002) domain scores. Over the follow-up period, declines on tests of language (β, -0.019; 95% CI, -0.034 to -0.005) and memory (β, -0.032; 95% CI, -0.051 to -0.012) were significantly greater for participants with impaired stereo acuity compared with those without such impairment.Conclusions and relevanceThese findings suggest that the association between vision and cognition differs between visual acuity, contrast sensitivity, and stereo acuity and that patterns of cognitive decline may differ by type of vision impairment, with impaired contrast sensitivity being associated with declines across more cognitive domains than other measures of visual functioning.

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GENETICS : ASSOCIATION OF GENETIC VARIATION OF TOMM40 WITH COGNITIVE DECLINE IN OLDER ADULTS: THE SONIC STUDY

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