Ontology highlight
ABSTRACT:
SUBMITTER: Villa-Perez P
PROVIDER: S-EPMC6185772 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Villa-Pérez Pablo P Merino Beatriz B Fernández-Díaz Cristina M CM Cidad Pilar P Lobatón Carmen D CD Moreno Alfredo A Muturi Harrison T HT Ghadieh Hilda E HE Najjar Sonia M SM Leissring Malcolm A MA Cózar-Castellano Irene I Perdomo Germán G
Metabolism: clinical and experimental 20180808
The role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood.<h4>Objective</h4>This study aimed to clarify whether IDE is a major mediator of insulin clearance, and to define its role in the etiology of hepatic insulin resistance.<h4>Methods</h4>We generated mice with liver-specific deletion of Ide (L-IDE-KO) and assessed insulin clearance and action.<h4>Results</h4>L-IDE-KO mice exhibited higher (~20%) fasting and n ...[more]