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Super-resolution imaging via aperture modulation and intensity extrapolation.

ABSTRACT: High-resolution telescopic imaging is of great importance in astronomy. Compared to the complexity and huge cost of constructing extremely-large telescopes, super-resolution technique which breaks the diffraction limit of the imaging system can enhance the spatial resolution with compact setup and low cost. In this paper, a novel super-resolution telescopic imaging method based on aperture modulation and intensity extrapolation is demonstrated, with both simulated and experimental studies performed. The simulation results show that the method can enhance the resolving power of a diffraction-limited telescopic imaging system by >5 times in noise-free case, and the improvement still reaches ~1.8 times with a signal-to-noise ratio of only ~10. The preliminary experimental results show a resolution enhancement of ~1.36 times for the limitations of the experimental setup. Better performance is possible with the images for reconstruction denoised and registered more precisely. The method is also useful in wide-field microscopy.

SUBMITTER: Xu B

PROVIDER: S-EPMC6185970 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Super-resolution imaging via aperture modulation and intensity extrapolation.

Xu Biao B Wang Zhiqiang Z He Jinping J

Scientific reports 20181012 1

High-resolution telescopic imaging is of great importance in astronomy. Compared to the complexity and huge cost of constructing extremely-large telescopes, super-resolution technique which breaks the diffraction limit of the imaging system can enhance the spatial resolution with compact setup and low cost. In this paper, a novel super-resolution telescopic imaging method based on aperture modulation and intensity extrapolation is demonstrated, with both simulated and experimental studies perfor ...[more]

PMID: 30315198

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Project description:BackgroundNoninvasive and functional imaging of the focal liver lesion (FLL) vasculature at microscopic scales is clinically challenging. We investigated the feasibility of using super-resolution ultrasound (SR-US) imaging for visualizing and quantifying the microvasculature of intraparenchymal FLLs.MethodsPatients with FLLs between June 2022 and February 2023 were prospectively screened. Following bolus injection of microbubbles at clinical concentration, SR-US was performed using a high frame rate (350-500 Hz) modified ultrasound scanner and a convex array transducer with a central frequency of 3.1 MHz.ResultsIn total, 47 pathologically proven FLLs at a depth of 5.7 ± 1.7 cm (mean ± standard deviation) were included: 30 hepatocellular carcinomas (HCC), 11 liver metastases (LM), and 6 focal nodular hyperplasias (FNH). The smallest detectable vessel size of the hepatic microvasculature was 128.4 ± 18.6 μm (mean ± standard deviation) at a depth of 8 cm. Significant differences were observed among the three types of lesions in terms of pattern categories, vessel density, minimum flow velocity, and perfusion index. We observed higher vessel density for FNH versus liver parenchyma (p < 0.001) as well as fractal dimension and local flow direction entropy value for FNH versus HCC (p = 0.002 and p < 0.001, respectively) and for FNH versus LM (p = 0.006 and p = 0.002, respectively).ConclusionMultiparametric SR-US showed that these three pathological types of FLLs have specific microvascular phenotypes. Vessel density, fractal dimension and local flow direction entropy served as valuable parameters in distinguishing between benign and malignant FLLs.Trial registrationClinicalTrials.gov (NCT06018142).Relevance statementMultiparametric SR-US imaging offers precise morphological and functional assessment of the microvasculature of intraparenchymal focal liver lesions, providing insights into tumor heterogeneity and angiogenesis.Key pointsSuper-resolution (SR)-US imaging allowed morphological and functional evaluation of intraparenchymal hepatic lesion microvasculature. Hepatocellular carcinoma, liver metastasis, and focal nodular hyperplasia exhibit distinct microvascular architectures and hemodynamic profiles. Multiparametric microvasculature characterization via SR-US imaging facilitates the differentiation between benign and malignant microvascular phenotypes.

Dataset Information

Super-resolution imaging via aperture modulation and intensity extrapolation.

Publications

Super-resolution imaging via aperture modulation and intensity extrapolation.

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