Decreased plasma C-reactive protein levels in APOE ?4 allele carriers.

ABSTRACT: Objective:Apolipoprotein E (APOE) ?4 allele is a well-established risk factor in Alzheimer's disease (AD). Here, we assessed the effects of APOE polymorphism on cardiovascular, metabolic, and inflammation-related parameters in population-based cohorts. Methods:Association of cardiovascular, metabolic, and inflammation-related parameters with the APOE polymorphism in a large Finnish Metabolic Syndrome in Men (METSIM) cohort and Finnish Geriatric Intervention study to prevent cognitive impairment and disability (FINGER) were investigated. Brain-specific effects were addressed in postmortem brain samples. Results:Individuals carrying the APOE ?4 allele displayed significantly elevated serum/plasma LDL cholesterol and apolipoprotein B levels. APOE ?3?4 and ?4?4 significantly associated with lower levels of plasma high-sensitivity C-reactive protein (hs-CRP). Plasma amyloid-? 42 (A?42) and reduced hs-CRP levels showed an association independently of the APOE status. Interpretation:These data suggest that the APOE ?4 allele associates with lower levels of hs-CRP in individuals without dementia. Moreover, A?42 may encompass anti-inflammatory effects reflected by reduced hs-CRP levels.

SUBMITTER: Martiskainen H 

PROVIDER: S-EPMC6186931 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature