Ontology highlight
ABSTRACT:
SUBMITTER: Schaffner I
PROVIDER: S-EPMC6186958 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Schäffner Iris I Minakaki Georgia G Khan M Amir MA Balta Elli-Anna EA Schlötzer-Schrehardt Ursula U Schwarz Tobias J TJ Beckervordersandforth Ruth R Winner Beate B Webb Ashley E AE DePinho Ronald A RA Paik Jihye J Wurst Wolfgang W Klucken Jochen J Lie D Chichung DC
Neuron 20180906 6
Autophagy is a conserved catabolic pathway with emerging functions in mammalian neurodevelopment and human neurodevelopmental diseases. The mechanisms controlling autophagy in neuronal development are not fully understood. Here, we found that conditional deletion of the Forkhead Box O transcription factors FoxO1, FoxO3, and FoxO4 strongly impaired autophagic flux in developing neurons of the adult mouse hippocampus. Moreover, FoxO deficiency led to altered dendritic morphology, increased spine d ...[more]