Dataset Information

NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression

ABSTRACT: By precisely dissected LC-MS/MS for proteomics and phosphoproteomics, we found that deletion of NRBF2 disrupts neurogenesis-related protein network in the DG, such as neurogenesis, cell development, cell morphogenesis, cellular homeostasis, and synaptic plasticity.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Shaoqi Zhang

LAB HEAD: Jian-Guo Chen

PROVIDER: PXD034382 | Pride | 2023-10-24

REPOSITORIES: Pride

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Publications

Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression.

Zhang Shao-Qi SQ Deng Qiao Q Zhu Qi Q Hu Zhuang-Li ZL Long Li-Hong LH Wu Peng-Fei PF He Jin-Gang JG Chen Hong-Sheng HS Yue Zhenyu Z Lu Jia-Hong JH Wang Fang F Chen Jian-Guo JG

Cell discovery 20230829 1

Dysfunctional autophagy and impairment of adult hippocampal neurogenesis (AHN) each contribute to the pathogenesis of major depressive disorder (MDD). However, whether dysfunctional autophagy is linked to aberrant AHN underlying MDD remains unclear. Here we demonstrate that the expression of nuclear receptor binding factor 2 (NRBF2), a component of autophagy-associated PIK3C3/VPS34-containing phosphatidylinositol 3-kinase complex, is attenuated in the dentate gyrus (DG) under chronic stress. NRB ...[more]

PMID: 37644025

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