Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC6188138 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Wang Li L Zhang Yujuan Y Liu Kangdong K Chen Hanyong H Yang Ran R Ma Xiaoli X Kim Hong-Gyum HG Bode Ann M AM Kim Dong Joon DJ Dong Zigang Z
Oncotarget 20180206 76
Carnosol is a phenolic diterpene that is isolated from rosemary, sage, and oregano. It has been reported to possess anti-oxidant, anti-inflammatory, and anti-cancer properties. However, the molecular mechanism of carnosol's activity against gastric cancer has not been investigated. Herein, we report that carnosol is an RSK2 inhibitor that attenuates gastric cancer growth. Carnosol reduced anchorage-dependent and -independent gastric cancer growth by inhibiting the RSKs-CREB signaling pathway. Th ...[more]