Ontology highlight
ABSTRACT:
SUBMITTER: Gray KT
PROVIDER: S-EPMC6190845 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Gray Kevin T KT Stefen Holly H Ly Thu N A TNA Keller Christopher J CJ Colpan Mert M Wayman Gary A GA Pate Edward E Fath Thomas T Kostyukova Alla S AS
Frontiers in molecular neuroscience 20181009
There are many unanswered questions about the roles of the actin pointed end capping and actin nucleation by tropomodulins (Tmod) in regulating neural morphology. Previous studies indicate that Tmod1 and Tmod2 regulate morphology of the dendritic arbor and spines. Tmod3, which is expressed in the brain, had only a minor influence on morphology. Although these studies established a defined role of Tmod in regulating dendritic and synaptic morphology, the mechanisms by which Tmods exert these effe ...[more]