Elevated Interleukin-36α And CD4⁺IL-36α⁺T Cells Are Involved in the Pathogenesis of Graves' Disease.

ABSTRACT: Background: IL-36α is involved in the pathogenesis of a variety of autoimmune diseases, but the relationship between IL-36α and Graves' disease (GD) has rarely investigated. In the present study, we aimed to explore the expression of IL-36α and elucidate the potential role of IL-36α in GD. Methods: The expression of IL-36α mRNA in peripheral blood mononuclear cells (PBMCs) from 32 newly diagnosed GD patients, 15 refractory GD patients and 30 normal controls (NC) was examined using quantitative real-time polymerase chain reaction (qRT-PCR). The level of IL-36α in serum from 46 newly diagnosed GD patients, 10 refractory GD patients and 24 NC was measured using enzyme linked immunosorbent assay (ELISA). The percentage of CD4⁺IL-36α⁺T cells was detected by f

SUBMITTER: Yao QM 

PROVIDER: S-EPMC6190875 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature