Elevated IL-6R on CD4+ T cells promotes IL-6 driven Th17 cell responses in patients with T1R leprosy reactions.
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ABSTRACT:
SUBMITTER: Saini C
PROVIDER: S-EPMC7493991 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Elevated IL-6R on CD4<sup>+</sup> T cells promotes IL-6 driven Th17 cell responses in patients with T1R leprosy reactions.
Saini Chaman C Srivastava Rupesh K RK Tarique Mohd M Kurra Santosh S Khanna Neena N Ramesh V V Sharma Alpana A
Scientific reports 20200915 1
Th17 cells play vital role during pathogenesis of leprosy reactions. Previously, we have reported that IL-23 is involved in Th17 cells differentiation. Subsequently, our group also showed that IL-6 induces Th17 cell differentiation along with TGF-β in leprosy reactions. Here, we next asked the question that whether IL-6 or IL-23 induced Th17 cells are different in nature? In this study, Type 1 Reactions (T1R) showed significantly (p < 0.001) higher percentage of IL-17A producing CD4<sup>+</sup>I ...[more]
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