Dataset Information

Knowledge, attitudes, and planned practice of HIV-positive to HIV-positive transplantation in US transplant centers.

ABSTRACT:

Background

HIV+ donor organs can now be transplanted into HIV+ recipients (HIV D+/R+) following the HIV Organ Policy Equity (HOPE) Act. Implementation of the HOPE Act requires transplant center awareness and support of HIV D+/R+ transplants.

Methods

To assess center-level barriers to implementation, we surveyed 209 transplant centers on knowledge, attitudes, and planned HIV D+/R+ protocols.

Results

Responding centers (n = 114; 56%) represented all UNOS regions. Fifty centers (93 organ programs) planned HIV D+/R+ protocols (kidney n = 48, liver n = 34, pancreas n = 8, heart n = 2, lung = 1), primarily in the eastern United States (28/50). Most (91.2%) were aware that HIV D+/R+ transplantation is legal; 21.4% were unaware of research restrictions. Respondents generally agreed with HOPE research criteria except the required experience with ≥5 HIV+ transplants by organ type. Centers planning HIV D+/R+ protocols had higher transplant volume, HIV+ recipient volume, increased infectious risk donor utilization, and local HIV prevalence (P < 0.01). Centers not planning HIV D+/R+ protocols were more likely to believe their HIV+ candidates would not accept HIV+ donor organs (P < 0.001). Most centers (83.2%) supported HIV+ living donation.

Conclusions

Although many programs plan HIV D+/R+ transplantation, center-level barriers remain including geographic clustering of kidney/liver programs and concerns about HIV+ candidate willingness to accept HIV+ donor organs.

SUBMITTER: Van Pilsum Rasmussen SE

PROVIDER: S-EPMC6191317 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Publications

Knowledge, attitudes, and planned practice of HIV-positive to HIV-positive transplantation in US transplant centers.

Van Pilsum Rasmussen Sarah E SE Bowring Mary Grace MG Shaffer Ashton A AA Henderson Macey L ML Massie Allan A Tobian Aaron A R AAR Segev Dorry L DL Durand Christine M CM

Clinical transplantation 20180831 10

<h4>Background</h4>HIV+ donor organs can now be transplanted into HIV+ recipients (HIV D+/R+) following the HIV Organ Policy Equity (HOPE) Act. Implementation of the HOPE Act requires transplant center awareness and support of HIV D+/R+ transplants.<h4>Methods</h4>To assess center-level barriers to implementation, we surveyed 209 transplant centers on knowledge, attitudes, and planned HIV D+/R+ protocols.<h4>Results</h4>Responding centers (n = 114; 56%) represented all UNOS regions. Fifty center ...[more]

PMID: 30074638

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Dataset Information

Knowledge, attitudes, and planned practice of HIV-positive to HIV-positive transplantation in US transplant centers.

Background

Methods

Results

Conclusions

Publications

Knowledge, attitudes, and planned practice of HIV-positive to HIV-positive transplantation in US transplant centers.

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