Ontology highlight
ABSTRACT:
SUBMITTER: Bielekova B
PROVIDER: S-EPMC6191370 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Cold Spring Harbor perspectives in medicine 20190501 5
Daclizumab is a humanized monoclonal antibody that prevents formation of high-affinity interleukin (IL)-2 receptor (IL-2R). Because activated T cells up-regulate high-affinity IL-2R and IL-2 is used to grow activated T cells in vitro, daclizumab was envisioned to selectively inhibit activated T cells. However, the mechanism of action (MOA) of daclizumab is surprisingly broad and it includes many unanticipated effects on innate immunity. Specifically, daclizumab modulates the development of innat ...[more]