Accuracy Improvement of In-line Near-Infrared Spectroscopic Moisture Monitoring in a Fluidized Bed Drying Process.

ABSTRACT: An exploratory analysis of a large representative dataset obtained in a fluidized bed drying process of a pharmaceutical powder has revealed a significant correlation of spectral intensity with granulate humidity in the whole studied range of 1091.8-2106.5 nm. This effect was explained by the dependence of powder refractive properties, and hence light penetration depth, on the water content. The phenomenon exhibited a close spectral similarity to the well-known stochastic variation of spectral intensities caused by the process turbulence (the so-called "scatter effect"). Therefore, any traditional scatter-corrective preprocessing incidentally eliminates moisture-correlated variance from the data. To preserve this additional information for a more precise moisture calibration, a time-domain averaging of spectral variables has been suggested. Its application resulted in a distinct improvement of prediction accuracy, as compared to the scatter-corrected data. Further improvement of the model performance was achieved by the application of a dynamic focusing strategy when adjusting the model to a drying process stage. Probe fouling was shown to have a minor effect on prediction accuracy. The study resulted in a considerable reduction of the root-mean-square error of in-line moisture monitoring to 0.1%, which is close to the reference method's reproducibility and significantly better than previously reported results.

SUBMITTER: Bogomolov A 

PROVIDER: S-EPMC6192013 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature