Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC6192412 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Li Liping L Zang Liqun L Zhang Feiran F Chen Junchen J Shen Hui H Shu Liqi L Liang Feng F Feng Chunyue C Chen Deng D Tao Huikang H Xu Tianlei T Li Ziyi Z Kang Yunhee Y Wu Hao H Tang Lichun L Zhang Pumin P Jin Peng P Shu Qiang Q Li Xuekun X
Human molecular genetics 20170701 13
Fat mass and obesity-associated gene (FTO) is a member of the Fe (II)- and oxoglutarate-dependent AlkB dioxygenase family and is linked to both obesity and intellectual disability. The role of FTO in neurodevelopment and neurogenesis, however, remains largely unknown. Here we show that FTO is expressed in adult neural stem cells and neurons and displays dynamic expression during postnatal neurodevelopment. The loss of FTO leads to decreased brain size and body weight. We find that FTO deficiency ...[more]