Ontology highlight
ABSTRACT:
SUBMITTER: Rydyznski CE
PROVIDER: S-EPMC6192537 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Rydyznski Carolyn E CE Cranert Stacey A SA Zhou Julian Q JQ Xu Heping H Kleinstein Steven H SH Singh Harinder H Waggoner Stephen N SN
Cell reports 20180901 13
Somatic hypermutation of immunoglobulin sequences in germinal center (GC) reactions must be optimized to elicit high-affinity, protective antibodies after vaccination. We expose natural killer (NK) cells as robust negative regulators of somatic hypermutation in antigen-reactive B cells. NK cells restrict follicular helper T cell (T<sub>FH</sub>) and GC B cell frequencies and titers of antigen-specific immunoglobulin after administration of alum-adjuvanted hapten-protein conjugate vaccines. This ...[more]