Ontology highlight
ABSTRACT:
SUBMITTER: Rosenberg RN
PROVIDER: S-EPMC6192700 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Rosenberg Roger N RN Fu Min M Lambracht-Washington Doris D
Journal of neuroimmunology 20180611
Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1-42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels a ...[more]