Ontology highlight
ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC6193951 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Zhang Wenbo W Niu Xiaogang X Ding Jienv J Hu Yunfei Y Jin Changwen C
Scientific reports 20181018 1
The thioredoxin (Trx)-coupled arsenate reductase (ArsC) is a family of enzymes that catalyzes the reduction of arsenate to arsenite in the arsenic detoxification pathway. The catalytic cycle involves a series of relayed intramolecular and intermolecular thiol-disulfide exchange reactions. Structures at different reaction stages have been determined, suggesting significant conformational fluctuations along the reaction pathway. Herein, we use two state-of-the-art NMR methods, the chemical exchang ...[more]