Ontology highlight
ABSTRACT:
SUBMITTER: Scott H
PROVIDER: S-EPMC6194281 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Scott Harry H Huang Wei W Bann James G JG Taylor Derek J DJ
Protein science : a publication of the Protein Society 20180901 9
The beta pore-forming proteins (β-PFPs) are a large class of polypeptides that are produced by all Kingdoms of life to contribute to their species' own survival. Pore assembly is a sophisticated multi-step process that includes receptor/membrane recognition and oligomerization events, and is ensued by large-scale structural rearrangements, which facilitate maturation of a prepore into a functional membrane spanning pore. A full understanding of pore formation, assembly, and maturation has tradit ...[more]