Ontology highlight
ABSTRACT:
SUBMITTER: Iacovache I
PROVIDER: S-EPMC4947156 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Iacovache Ioan I De Carlo Sacha S Cirauqui Nuria N Dal Peraro Matteo M van der Goot F Gisou FG Zuber Benoît B
Nature communications 20160713
Owing to their pathogenical role and unique ability to exist both as soluble proteins and transmembrane complexes, pore-forming toxins (PFTs) have been a focus of microbiologists and structural biologists for decades. PFTs are generally secreted as water-soluble monomers and subsequently bind the membrane of target cells. Then, they assemble into circular oligomers, which undergo conformational changes that allow membrane insertion leading to pore formation and potentially cell death. Aerolysin, ...[more]