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Phosphorescent cationic iridium(iii) complexes dynamically bound to cyclodextrin vesicles: applications in live cell imaging.

ABSTRACT: We report cationic Ir(iii) complexes functionalized with adamantyl groups designed to bind to ?-cyclodextrin vesicles (CDV) with high affinity (K _a = 1 × 10⁶ M^-1). The emission of the complexes is tuned by changing the nature of the cyclometalating ligands. The host-guest adduct of CDV and Ir(iii) complexes shows increased and significantly blue-shifted emission due to the lower mobility of the Ir(iii)-complexes residing in the less polar environment of the vesicle surface. Ir(iii)-decorated CDV are efficiently taken up by cells and can be used in live cell imaging. The CDV act as carriers to transport the phosphorescent complexes into cells where they selectively stain mitochondria.

SUBMITTER: Schibilla F

PROVIDER: S-EPMC6194495 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Phosphorescent cationic iridium(iii) complexes dynamically bound to cyclodextrin vesicles: applications in live cell imaging.

Schibilla Frauke F Holthenrich Anna A Song Boyi B Linard Matos Anna Lívia AL Grill David D Rota Martir Diego D Gerke Volker V Zysman-Colman Eli E Ravoo Bart Jan BJ

Chemical science 20180809 40

We report cationic Ir(iii) complexes functionalized with adamantyl groups designed to bind to β-cyclodextrin vesicles (CDV) with high affinity (K a = 1 × 106 M-1). The emission of the complexes is tuned by changing the nature of the cyclometalating ligands. The host-guest adduct of CDV and Ir(iii) complexes shows increased and significantly blue-shifted emission due to the lower mobility of the Ir(iii)-complexes residing in the less polar environment of th ...[more]

PMID: 30429991

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