Ontology highlight
ABSTRACT:
SUBMITTER: Obata-Ninomiya K
PROVIDER: S-EPMC6196506 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Obata-Ninomiya Kazushige K Ishiwata Kenji K Nakano Hisanobu H Endo Yusuke Y Ichikawa Tomomi T Onodera Atsushi A Hirahara Kiyoshi K Okamoto Yoshitaka Y Kanuka Hirotaka H Nakayama Toshinori T
Proceedings of the National Academy of Sciences of the United States of America 20181001 42
Memory T helper (mTh) cells play important roles in the reinfection of pathogens and drive the pathogenesis of diseases. While recent studies have characterized the pathogenic mTh2 cell subpopulations driving allergic inflammation, those that induce immune responses against helminth infection remain unknown. We found that IL-5-producing CXCR6<sup>+</sup>ST2<sup>+</sup>CD44<sup>+</sup> mTh2 cells play a crucial role in the IL-33-dependent inhibition of the fecundity of helminth, whereas other ST2 ...[more]