Dataset Information

Calprotectin as a smoldering activity detection tool and renal prognosis biomarker in ANCA associated vasculitis.

ABSTRACT:

Background

Calprotectin is produced by neutrophils and macrophages, and released during the acute phase of the ANCA vasculitis. The aim of our study was to determine if serum and urine calprotectin are disease activity and prognosis biomarkers in ANCA vasculitis patients during remission.

Methods

Forty-two ANCA vasculitis patients were included. Twenty-seven patients were in remission phase under immunosuppressive therapy, and 15 patients were in the acute phase. Four healthy controls were included. We determined calprotectin in serum and urine samples at the time of the inclusion. We recorded the incidence of relapse and the evolution of GFR, proteinuria, hematuria, and C reactive protein and ANCA titer during 24 months of follow-up.

Results

In remission phase, serum calprotectin was higher than in healthy controls but lower compared to acute patients (p = 0.05). Serum calprotectin at inclusion was higher in patients who increased proteinuria during follow-up (p = 0.04), with hematuria (p = 0.08), and with non-decreasing ANCA titer (p = 0.0019). Serum calprotectin at inclusion in stable patients who subsequently decreased GFR during follow-up was higher compared with those with a stable or improving GFR (p = 0.03). Urine calprotectin was lower in patients with sclerotic histology in remission (p = 0.03) and acute phase (p = 0.12) compared to the rest of histologies.

Conclusions

Worsening of renal function, hematuria, rising proteinuria and non-decreasing ANCA correlated with higher levels of serum calprotectin at recruitment. Low urine calprotectin was found in patients with sclerotic histology. Calprotectin during remission in ANCA vasculitis may be useful to identify subclinical inflammation and worse renal prognosis patients.

SUBMITTER: Martinez Valenzuela L

PROVIDER: S-EPMC6197669 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Calprotectin as a smoldering activity detection tool and renal prognosis biomarker in ANCA associated vasculitis.

Martinez Valenzuela Laura L Draibe Juliana J Quero Ramos Maria M Fulladosa Oliveras Xavier X Melilli Edoardo E Cruzado Garrit Josep Maria JM Torras Ambrós Juan J

PloS one 20181022 10

<h4>Background</h4>Calprotectin is produced by neutrophils and macrophages, and released during the acute phase of the ANCA vasculitis. The aim of our study was to determine if serum and urine calprotectin are disease activity and prognosis biomarkers in ANCA vasculitis patients during remission.<h4>Methods</h4>Forty-two ANCA vasculitis patients were included. Twenty-seven patients were in remission phase under immunosuppressive therapy, and 15 patients were in the acute phase. Four healthy cont ...[more]

PMID: 30347000

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Dataset Information

Calprotectin as a smoldering activity detection tool and renal prognosis biomarker in ANCA associated vasculitis.

Background

Methods

Results

Conclusions

Publications

Calprotectin as a smoldering activity detection tool and renal prognosis biomarker in ANCA associated vasculitis.

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