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Engineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor.

ABSTRACT: In the past 10 years, with the increase of investment in clinical nano-gene therapy, there are many trials that have been discontinued due to poor efficacy and serious side effects. Therefore, it is particularly important to design a suitable gene delivery system. In this paper, we introduce the application of liposomes, polymers, and inorganics in gene delivery; also, different modifications with some stimuli-responsive systems can effectively improve the efficiency of gene delivery and reduce cytotoxicity and other side effects. Besides, the co-delivery of chemotherapy drugs with a drug tolerance-related gene or oncogene provides a better theoretical basis for clinical cancer gene therapy.

SUBMITTER: Xiao Y

PROVIDER: S-EPMC6197778 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Engineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor.

Xiao Yao Y Shi Kun K Qu Ying Y Chu Bingyang B Qian Zhiyong Z

Molecular therapy. Methods & clinical development 20180922

In the past 10 years, with the increase of investment in clinical nano-gene therapy, there are many trials that have been discontinued due to poor efficacy and serious side effects. Therefore, it is particularly important to design a suitable gene delivery system. In this paper, we introduce the application of liposomes, polymers, and inorganics in gene delivery; also, different modifications with some stimuli-responsive systems can effectively improve the efficiency of gene delivery and reduce ...[more]

PMID: 30364598

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