Genotype effects contribute to variation in longitudinal methylome patterns in older people.
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ABSTRACT:
SUBMITTER: Zhang Q
PROVIDER: S-EPMC6198530 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Genotype effects contribute to variation in longitudinal methylome patterns in older people.
Zhang Qian Q Marioni Riccardo E RE Robinson Matthew R MR Higham Jon J Sproul Duncan D Wray Naomi R NR Deary Ian J IJ McRae Allan F AF Visscher Peter M PM
Genome medicine 20181022 1
<h4>Background</h4>DNA methylation levels change along with age, but few studies have examined the variation in the rate of such changes between individuals.<h4>Methods</h4>We performed a longitudinal analysis to quantify the variation in the rate of change of DNA methylation between individuals using whole blood DNA methylation array profiles collected at 2-4 time points (N = 2894) in 954 individuals (67-90 years).<h4>Results</h4>After stringent quality control, we identified 1507 DNA methylati ...[more]
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