Ontology highlight
ABSTRACT:
SUBMITTER: Haines RR
PROVIDER: S-EPMC6200601 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Haines Robert R RR Barwick Benjamin G BG Scharer Christopher D CD Majumder Parimal P Randall Troy D TD Boss Jeremy M JM
Journal of immunology (Baltimore, Md. : 1950) 20180919 9
B cells undergo epigenetic remodeling as they differentiate into Ab-secreting cells (ASC). LSD1 is a histone demethylase known to decommission active enhancers and cooperate with the ASC master regulatory transcription factor Blimp-1. The contribution of LSD1 to ASC formation is poorly understood. In this study, we show that LSD1 is necessary for proliferation and differentiation of mouse naive B cells (nB) into plasmablasts (PB). Following LPS inoculation, LSD1-deficient hosts exhibited a 2-fol ...[more]