Ontology highlight
ABSTRACT:
SUBMITTER: Kerenyi MA
PROVIDER: S-EPMC3687337 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Kerenyi Marc A MA Shao Zhen Z Hsu Yu-Jung YJ Guo Guoji G Luc Sidinh S O'Brien Kassandra K Fujiwara Yuko Y Peng Cong C Nguyen Minh M Orkin Stuart H SH
eLife 20130618
Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis, combining global occupancy of Lsd1, genome-wide analysis of its substrates H3K4 monomethylation and dimethylation, and gene expression profiling, reveals that Lsd1 represses hematopoietic stem and progenitor cell (HSPC) gene expression programs during hematopoietic differ ...[more]