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Ceftazidime-Avibactam Susceptibility Breakpoints against Enterobacteriaceae and Pseudomonas aeruginosa.


ABSTRACT: Clinical susceptibility breakpoints against Enterobacteriaceae and Pseudomonas aeruginosa for the ceftazidime-avibactam dosage regimen of 2,000/500 mg every 8 h (q8h) by 2-h intravenous infusion (adjusted for renal function) have been established by the FDA, CLSI, and EUCAST as susceptible (MIC, ?8 mg/liter) and resistant (MIC, >8 mg/liter). The key supportive data from pharmacokinetic/pharmacodynamic analyses, in vitro surveillance, including molecular understanding of relevant resistance mechanisms, and efficacy in regulatory clinical trials are collated and analyzed here.

SUBMITTER: Nichols WW 

PROVIDER: S-EPMC6201065 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Ceftazidime-Avibactam Susceptibility Breakpoints against Enterobacteriaceae and Pseudomonas aeruginosa.

Nichols Wright W WW   Stone Gregory G GG   Newell Paul P   Broadhurst Helen H   Wardman Angela A   MacPherson Merran M   Yates Katrina K   Riccobene Todd T   Critchley Ian A IA   Das Shampa S  

Antimicrobial agents and chemotherapy 20181024 11


Clinical susceptibility breakpoints against <i>Enterobacteriaceae</i> and <i>Pseudomonas aeruginosa</i> for the ceftazidime-avibactam dosage regimen of 2,000/500 mg every 8 h (q8h) by 2-h intravenous infusion (adjusted for renal function) have been established by the FDA, CLSI, and EUCAST as susceptible (MIC, ≤8 mg/liter) and resistant (MIC, >8 mg/liter). The key supportive data from pharmacokinetic/pharmacodynamic analyses, <i>in vitro</i> surveillance, including molecular understanding of rele  ...[more]

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