Ontology highlight
ABSTRACT:
SUBMITTER: Papp-Wallace KM
PROVIDER: S-EPMC6639593 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Papp-Wallace Krisztina M KM Zeiser Elise T ET Becka Scott A SA Park Steven S Wilson Brigid M BM Winkler Marisa L ML D'Souza Roshan R Singh Indresh I Sutton Granger G Fouts Derrick E DE Chen Liang L Kreiswirth Barry N BN Ellis-Grosse Evelyn J EJ Drusano George L GL Perlin David S DS Bonomo Robert A RA
The Journal of infectious diseases 20190701 4
Previously, by targeting penicillin-binding protein 3, Pseudomonas-derived cephalosporinase (PDC), and MurA with ceftazidime-avibactam-fosfomycin, antimicrobial susceptibility was restored among multidrug-resistant (MDR) Pseudomonas aeruginosa. Herein, ceftazidime-avibactam-fosfomycin combination therapy against MDR P. aeruginosa clinical isolate CL232 was further evaluated. Checkerboard susceptibility analysis revealed synergy between ceftazidime-avibactam and fosfomycin. Accordingly, the resis ...[more]